SYSTEMEU project - Open Call for Interregional Innovation Proposals in the areas of digital transformation of the Healthcare, Energy and Mobility sectors

The Horizon Europe co-funded SYSTEMEU project is launching its Financial Support to Third Parties (FSTP) Open Call, with €7.55 million in funding available for interregional innovation projects focused on the digital transformation of healthcare, energy and mobility. The Horizon Europe project will support five to eight interregional projects developing and testing innovative digital solutions across five European regions. SYSTEMEU offers three funding pathways, tailored to the size, geographical reach and composition of each consortium. The call focuses on the digital transformation of the Healthcare, Energy, and Mobility sectors.

Topic 1: Healthcare (Digital Health & Medtech)

This challenge focuses on the digital transformation of clinical workflows, medical services, and diagnostic pathways utilising advanced deep-tech solutions. It aims to enhance diagnostic accuracy, optimise specialised medical service delivery, and enable seamless, data-driven operations across modern healthcare ecosystems.

Topic 2: Energy (Decentralized, Clean & Smart Energy Networks)

This challenge focuses on the overarching digital transformation of regional and cross-border energy ecosystems. It remains completely open to any digital innovation, software architecture, data model, or optimisation methodology that accelerates the transition toward decentralized, clean, secure, and resilient energy systems, fostering overall resource efficiency and network optimization. 

Topic 3: Mobility (Intelligent Transport Systems & Logistics)

This challenge addresses the comprehensive digitisation of transportation operations, public transit, autonomous systems, and supply chain logistics. It is designed to welcome any software platform, data-driven architecture, or hardware-integrated digital solution that enhances the efficiency, cargo/passenger safety, connectivity, and environmental sustainability of transit networks. 

Eligible regions – SYSTEMEU funding territories: 

Bavaria (Germany), Norte (Portugal), Castile-León (Spain), Romania, Tuzla Canton (Bosnia and Herzegovina)

Who can apply?

Quadruple Helix: Universities, Research and Technology Organisations (RTO), Startups, SMEs, Large Enterprises, Public Authorities, Hospitals, NGOs 

Consortium requirements:

Refer to specific consortium requirements in open call text as they apply differently to Medium Projects or Small Projects or Flagship projects.

Projects must begin at a minimum Technology Readiness Level (TRL) 6 and reach TRL 8 during the project duration, taking technologies from validated prototypes to complete solutions demonstrated under operational conditions. Selected projects are expected to run for between 15 and 18 months, with implementation scheduled to begin in February and March 2027.

Financial Support:

• Total budget: €7 550 000
• Expected project budget: up to 2 200 000 EUR per flagship, and up to 1 100 000 EUR / 750 000 EUR for medium/small projects
• Max. funding per single beneficiary: €600 000 

Background information

The Regional Innovation Valley project SYSTEMEU, coordinated by the Strascheg Center for Entrepreneurship (Germany) and co-funded under Horizon Europe, is dedicated to advancing interconnected European innovation ecosystems and accelerate digital transformation in healthcare, energy and mobility. By connecting universities, research organisations, companies, public authorities and innovation actors across different regions, the project aims to reduce territorial innovation gaps, strengthen competitiveness and support the development of scalable solutions with economic and societal impact.

SYSTEMEU is launching its Financial Support to Third Parties (FSTP) Open Call, with €7.55 million in funding available for interregional innovation projects focused on the digital transformation of healthcare, energy and mobility. The Horizon Europe project will support five to eight interregional projects developing and testing innovative digital solutions across five European regions. SYSTEMEU offers three funding pathways, tailored to the size, geographical reach and composition of each consortium.